Traffic along the Kasarani-Mwiki road was disrupted on Tuesday morning after residents blocked it as they protested the killing of one of their own.
Some motorists were stuck for hours, while others were forced to use alternative routes amid confusion.
It was reported that the victim was fatally stabbed by suspected gang members on Monday morning, triggering uproar from the public, who blocked the road near St. Francis Hospital as they sought justice for the victim and his family.
The protestors are said to have laid stones across the road, barring vehicles from driving past the Stima area of the popular Nairobi estate.
Although details of the murder have yet to be made public, police officers in the area have arrived at the scene of the protests to calm the crowds.
Following the traffic disruption, commuters who rely on the road to access Nairobi's Central Business District and other roads were forced to sit in traffic as police officers tried to manage the situation.
In videos seen by Kenyans.co.ke, Public Service Vehicles (PSVs), including cab-hailing service drivers, were caught using estates and other feeder roads to get themselves out of the jam.
Motorists planning to use the road have been advised to use alternative routes to evade the traffic snarl-up.
This disruption comes just a few days after the busy Nairobi-Mombasa highway was blocked after protesters took over the road at the Kiboko area.
In that incident, the protesters blocked the road using large stones and burning tyres, effectively cutting off movement along the vital transport corridor.
They were similarly protesting the killing of a middle-aged man by a popular local businessman who reportedly teamed up with another individual to lynch the deceased.
The businessman, who also serves as a teacher in the area, was said to have accused the victim of stealing from his shop.
They were calling for the apprehension of the suspect, who was still walking free. At the height of the protests, officers deployed to restore calm hurled tear gas at them to disperse the crowd.
