Police have fired teargas at a group of 100 supporters of Opposition leader Raila Odinga and the National Super Alliance (NASA).
The police reportedly lobbed tear gas canisters after the youth began chanting "No Raila no peace" and anti-Uhuru slogans.
The youth are also reported to have engaged the police in running battles after barricading roads in the area with burning tyres.
The commotion began shortly after the NASA presidential candidate claimed that there had been "massive" fraud in yesterday's election.
In a press conference Wednesday morning, Mr Odinga rejected the provisional presidential results and claimed that hackers had gained entry into the IEBC system on Tuesday at around 12.40pm and created errors in the document that had presidential votes.
The current Presidential results show President Kenyatta leading with about 7.8 Million votes against Mr Odinga's 6.4 Million votes.
Meanwhile, protests have also been reported in Homa Bay and a section of Nairobi areas including Mathare and Kibera but police have responded swiftly.
Here are some photos from the Kisumu and mathare protest:
[caption caption="Kisumu protests"]
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[caption caption="police in Kisumu"]
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[caption caption="Tyres being burnt in Kisumu"]
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[caption caption="Situation at Mathare"]
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